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When you start with a natural progesterone and alter its chemical structure (typically so it can be patented), you make a synthetic progestin. Progestins can be found in Prempro and Provara, two hormone replacement products available with a prescription. However, when you alter progesterone to synthesize progestin, there may be complications that could arise that are not recognized by conventional medicine. In fact, the 2002 PDR states, "The effect of prolonged use of progestins on the pituitary, ovarian, adrenal, hepatic or uterine functions is unknown." Progestins can mimic the body's progesterone closely enough to bind progesterone receptor sites, but they do not deliver the full range of messages that a natural progesterone molecule would. Physiologically, progestin suppresses natural hormone production and can stress the liver. It takes 6-8 weeks for the body to clear progestins (vs 6-12 hours for progesterone). Additionally, progestins undermine the body's steroidal pathways and adrenal function and can therefore affect a patient's energy and vitality. Besides fatigue, the documented side effects include depression, anxiety and nervousness, migraines, nausea, edema, strokes and coronary artery spasms. Consequently, many physicians are moving to the use of plant-based oral micronized progesterone (OMP) in creams or oral forms. |